Abstract index

2. Cancer cytogenetics: hematological tumors

2.1

Inversion inv(19)(p13q13) as the First Chromosome Aberration causing a Heterozygous Targeted Disruption of an Oncogene

S. Röttgers , S. Bungaro , Enrica Privitera , A. Biondi , J. Harbott

2.2

Inferring something from seeing nothing – a cautionary MLL FISH tale

R.Harris , K.Taylor , Z.Broadfield , K.Cheung , C.Harrison , G.Jalali , M.Martineau , H.Robinson and A.Moorman

2.3

Detection of new specific chromosome aberrations in acute leukemia using molecular cytogenetic techniques

Laura van Zutven , Ellen van Drunen , Sandra Velthuizen , Berna Beverloo

2.4

An ANLL-M7 patient with acquired 21

A. Acar , G. Durakbasi , A. Zamanı , C. Ucar , U. Caliskan , R. Celik

2.5

MOLECULAR CYTOGENETIC ANALYSIS OF COMPLEX KARYOTYPES IN MULTIPLE MYELOMA

S. Alvarez , B. Saez , S. Afonso , A. Otero , J.L. García Miranda , D. Blesa , M. Urioste , J. Benítez , M.D. Odero , M.J. Calasanz , J.C. Cigudosa

2.6

Acute myeloid leukemia cases showing 5'AML1/3'ETO fusion resulting from insertion and inversion mechanisms

L. Anelli , A. Zagaria , F. Albano , L. Sebastio , R. La Starza , G. Rege-Cambrin , V. Liso , M. Rocchi , G. Specchia ,

2.7

Deletion of RARA gene region revealed by FISH in AML A case report

Eva Anghem, Anita Risell, Carina Wikhager, Inger Ögärd, Stefan Jacobsson, Birgitta Swolin.

2.8

Additional chromosomal abnormalities in two Ph+CML cases

A. Arghir, N. Berbec , D. Mut-Popescu , A. Lupu , A. Lungeanu

2.9

The use of interphase FISH in hematological malignancies. Report of two cases from Iceland.

Á.Arnardóttir, E.Sveinbjörnsdóttir, E.Guðmundsdóttir, H.Júlíusdóttir, M.Steinarsdóttir and J.H.Jóhannsson .

2.10

A. Athanasiadou, R. Saloum, I. Zorbas, A. Tsompanakou, I. Batsis, A.Fassas, A. Anagnostopoulos

2.11

CLONAL CHROMOSOME ABNORMALITIES IN PHILADELPHIA-NEGATIVE CELLS IN CML PATIENTS TREATED WITH STI-571.

M. Bernués , N. Govea , D. Heine , L. Torres , MA. Duran , A. Gutiérrez , A. Novo , A. Sampol , J. Besalduch J. Rosell .

2.12

Amplification of AML1 on a duplicated chromosome 21 defines a new patient subgroup in acute lymphoblastic leukaemia

H.M. Robinson, Z. Broadfield, K. Cheung, L. Harewood, R. Harris, M. Al-Obaidi, G. Jalali, M. Martineau, C. Mitchell, A. Moorman, S. Richards, K. Taylor, C. Harrison

2.13

Occurrence of an MLL/LAF4 fusion gene caused by the insertion ins(11;2)(q23;q11.2q11.2) in an infant with acute lymphoblastic leukemia (ALL)

J. Bruch , M. Wilda , A. Teigler-Schlegel , M. Metzler , J. Harbott , A. Borkhardt

2.14

Spectral karyotyping in a series of 38 patients with acute myeloid leukaemia

G. Calabrese , D. Fantasia , E. Morizio , M. De Cinque , M.G. Ciavarella , R. Di Gianfilippo , G. Perla , G. Gentile , A. Zatterale , L. Stuppia , P. Guanciali Franchi , G. Palka , .

2.15

Detection of chromosomal abnormalities related with prognosis in Smoldering Multiple Myeloma. Analyisis of 13q14.3 and 11q13 regions by FISH.

A. Carrió, L.Rosiñol, J. Bladé, M. Aymerich, M. Rozman, D. Costa, A. Arias, E. Monserrat, E. Campo .

2.16

Chromosome 7 instability and myelodysplasia in Shwachman syndrome

MP Cecchini , E Maserati , M Stefanelli , B Crescenzi , C Matteucci , A Minelli , C Mecucci , F Lo Curto , F Pasquali

2.17

Trisomy 15, as sole autosomal abnormality, and hematological malignancy

Dolors Costa, Ana Carrió, Amparo Arias, Josep Lluís Aguilar Benet Nomdedeu, Elías Campo

2.18

Is the clonal evolution an independent prognostic factor in CML?

E.Donti, P.Prontera, C.Ardisia, A.Bassetti, C. Gradassi, E.Bianchi, E.Gentileschi, G.Venti

2.19

ETV6 gene implication in leukaemia cases with 12p13 : Molecular cytogenetic study.

H. Elghezal, W. Brahim, H. Sennana, A. Saad

2.20

Genetic aberrations and immunoglobulin VH gene usage in chronic lymphocytic leukaemia

E Emanuelsson , G Tobin , U Thunberg , M Jansson , Richard Rosenquist , M Merup .

2.21

BCL3/IGH TRANSLOCATION T(14;19)(q32;q13) IN SPLENIC MARGINAL ZONE B-CELL LYMPHOMA: A REPORT OF TWO CASES AND A REVIEW OF THE LITERATURE

B. Espinet , M. Salido , I. Granada , A. Domingo, M. Xandri, J. Petit, F. Millá, S. Serrano, F. Solé,

2.22

Chromosome 21 tandem repetition and AML1 gene in acute leukemias

M.T. Ferro , M. Talavera, R. Hernaez , M.T. Sordo , J.M. Garcia-Sagredo , P. Garcia-Miguel , M. Fernández Guijarro , J. Lopez , C. Villalón , I. Vallcorba , I. Lopez Baltar , C. San Roman

2.23

The ATM gene analyses in peripheral blood lymphocytes of B-CLL patients.

A. Filip , D. Koczkodaj , Z.M. Rupniewska , E. Wasik-Szczepanek , A. Dmoszynska , J. Wojcierowski .

2.24

Expression of the reciprocal chimaeric gene ABL-BCR in CML patients with or without 5’ ABL and/or 3’BCR deletions.

M. Fournier, M. Lopez y Cadenas, V. Bours and C. Herens.

2.25

Deletion of derivative chromosome 9 in the Ph-positive Acute Myeloid Leukemias.

E.Giugliano , P. Scaravaglio , G.Rege-Cambrin , M. Fimognari , M. Mancini , C.Mecucci , A. Cuneo , G. Specchia , N.Testoni and G. Saglio .

2.26

Variant Philadelphia chromosome translocations in Chronic Myeloid Leukemia

M.G. Grimoldi , A. Benevento , S. Buiatiotis , S. Fiori , R. Malgara , E. Meroni and G. Coggi

2.27

FISH and PCR analysis in a preclinical phase of CML

N. Guercini, E. Di Bona, G. Saglio, D. Randi, R. Merlo, M.Stella

2.28

Inv(16) is not associated with favorable prognosis in Israeli AML patients-a multi-center retrospective analysis

A.Gural, M.Shtalrid, P.Raanani, S.Ben Neriah, N.Goldschmidt, O.Paltiel, D.Ben-Yehuda

2.29

Complex Chromosomal Abnormalities Five Years Before Leukaemia

R. Hain, G. Jalali, M. Martineau, M. McKinley, H. Robinson, C. Harrison

2.30

FISHing for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia.

C.J. Harrison, A.V. Moorman, Z.J. Broadfield, K-L. Cheung, R.L. Harris, H.M. Robinson, K.E. Taylor, G.R. Jalali, M. Martineau

2.31

Recurrent and new chromosome aberrations in myelodysplastic syndromes (MDS) disclosedby conventional and molecular cytogenetics

O.Haus , E.Duszeńko , I.Makowska , S.Potoczek , B.Mucha , K.Soszyńska , M.Całbecka , K.Skonieczka , K.Kuliczkowski

2.32

FISH in tumorcytogenetics: the optimal chose of methods - a single lab experience

B. Heinze, M. Locher and I. Hahntow

2.33

Clonal chromosome aberrations in Philadelphia-negative cells from CML patients treated with imatinib mesylate : report of two cases and review of the literature.

C. Herens, F. Baron, M. Jamar, A.C. Hellin, M. Fournier and V. Bours .

2.34

Comparative genomic hybridization (CGH) in detection of chromosomal changes in 120 childhood acute lymphoblastic leukemias. Update of results.

M.Holzerová, M.Jarošová, V.Mihál, H.Pospíšilová, B.Blažek, J. Starý, J.Zuna, J.Trka, D.Pospíšilová, M.Divoká, Z.Zemanová, O.Hrušák, V. Divoký, Z.Pikalová, K.Indrák

2.35

Inter- and intrachromosomal chromosome 1 aberrations in Non-Hodgkin Lymphoma as detected by multicolor banding and locus specific FISH analysis

Douglas E Horsman , Olga Ludkovski Joseph M Connors , Randy D Gascoyne , Wan L. Lam and Valia S Lestou ,

2.36

INTERPHASE FISH ANALYSIS OF CYTOGENETIC ABNORMALITIES IN B-CLL: A STUDY OF YOUNGER ADULTS PATIENTS.

L. Intropido , L. Doneda , E. Morra and L. Larizza .

2.37

FISH analysis for detection of MYC rearrangments in patients with Burkitt/Burkitt like lymphoma.

M.Jansson, B.Sander, M.Merup

2.38

High heterogeneity of MLL rearrangements in acute leukemias

M.Jarosova, M.Holzerova, V.Divoky, T.Papajik, M.Divoka, I.Lakoma, H.Pospisilova, S.Vlachova, A. Novosadova, J.Hubacek, E.Faber, L.Raida, K.Indrak

2.39

Masked t(2;8)(p12;q24) translocation within a highly complex karyotype detected in terminal phase mantle cell lymphoma

S J Jeffries , D J McMullan, E C Edwards, P S White, S J Rose, I C M MacLennan, T Simoyi, M J Griffiths

2.40

Gain of 11q23 in newly diagnosed patients with multiple myeloma detected by interphase cytogenetics

M. Kartal , F.W. Cremer , D. Hose , H. Goldschmidt , C.R. Bartram , A. Jauch

2.41

Chromosomal alterations by classical cytogenetics, flourescence in situ hybridization and comparative genomic hybridization in patients with acute myeloid leukemias

J. Kocki , M. Constantinou , M. Cioch , A. Dmoszyńska , B. Kałużewski and J. Wojcierowski

2.42

TP53 gene deletion and chromosome 12 trisomy in patients with B-cell chronic lymphocytic leukemia.

D. Koczkodaj , Z.M. Rupniewska , A. Filip , E. Wasik-Szczepanek , A. Bojarska-Junak , A. Dmoszynska , J. Wojcierowski

2.43

Deletion 5p15.2 in Unclassified Myelodysplastic Syndrome(MDS-U).

S.Kokkinou, S.Diamantopoulou, I.Sagriotou, L.Katabelisi, A.Varouta.

2.44

Complex karyotipe 46,XX, t(4;10)(q31;q22), del(11)(q23) in acute myeloid leukemia

A. Krstic, M. Miskovic, M. Guc-Scekic, D. Vujic, D. Djokic

2.45

Detection of a ETV6 gene rearrangement in five cases of atypical chronic myeloid leukemia with 5q chromosome abnormalities

A.Lazaridou, S.Mavroudi, K.Tsimirika, E.Georgiou, D.Mihou, M.Papaioannou, N.Panagiotou, J.I.Christakis.

2.46

MFISH analysis of t(14;18)-positive follicular lymphoma and correlation with gene expression data and clinical outcome

Valia S Lestou , Randy D Gascoyne , Laurie Sehn , Olga Ludkovski , Mukesh Chhanabhai , Richard J Klasa , Hervé Husson , Arnold S. Freedman , Joseph M Connors and Douglas E Horsman ,

2.47

MYELODYSPLASTIC SYNDROME IN CHILDHOOD: CYTOGENETIC RESULTS OF AN ITALIAN MULTICENTRIC STUDY

A.Leszl, G.Basso, A.Biondi, A.Cantù-Rainoldi, S.Fenu, F.Locatelli, D.Longoni, E. Rigon, L.Sainati, A.M.Testi, For the Italian Associacion for Pediatric Hemato-Oncology AIEOP

2.48

Characterisation by FISH of 21q rearrangements in myeloid malignancy

R. Lukeis, S. Grover Greenidge and M. Suter

2.49

Characterization of genomic deletions in derivative chromosome 9 in patients with chronic myeloid leukemia

T. Lundán , K. Porkka and S. Knuutila .

2.50

Trisomy 9 in a case of systemic mastocytosis associated with chronic myeloid disorder

A. Lungeanu , A. Arghir , I. Badea

2.51

Characterization of Leukemia-Lymphoma Cell Lines with Rearrangements in 3´-BCL11B: Evidence for a Specific Homeobox Activator Region

R.A.F. MacLeod, S. Nagel, D. Anders, M. Kaufmann and H.G.Drexler

2.52

Fluorescence in situ hybridization analysis of unusual chromosomal rearrangements in acute myeloid leukaemia involving the MLL gene

B. Marques , A.C. Sousa , P. Ambrósio , M. Jorge , H. Alaiz , J. Diamond , A.M. Pereira , M.J. Ribeiro , L. Vieira , M.G. Boavida

2.53

Involvement of dendritic cells in juvenile chronic myelomonocytic leukaemia shown by FISH on interphase nuclei

E Maserati , D Montagna , MP Cecchini , C Morerio , C Panarello , G Giorgiani , F Lo Curto , F Locatelli , R Maccario , F Pasquali

2.54

Interphase FISH study of patients with chronic lymphocytic leukaemia

C.H.M. Mellink , G.H. Schuring-Blom , W.J.M. Mackus , B.M. Heijdra , R.S.A. Rust , M.H.J. van Oers

2.55

ANALYSES OF 5q DELETIONS IN MYELOID MALIGNANCIES BY mBAND AND mFISH.

Michalová K. , Zemanová Z. , Bøezinová J. , Šindeláøová L. , Kurková Š. , Šišková M. , Èermák J. , Neuwirtová R. , Šponerová D.

2.56

Incidence and distribution of jumping translocations in multiple myeloma.

F. Morel , M.-J. Le Bris , A. Herry , C. Berthou , P. Bourquard , P. Morice , M. De Braekeleer ,

2.57

Duplication and amplification of MLL gene in malignant Duplication and amplification of MLL gene in malignant myeloid hemopathies

D. Mühlematter , V. Parlier , S. Mamin , V. Beyer , D. Ahmad , S. Arcioni , A. Bilbao , O. Bruzzese , L. Etter , N. Mercanton , M. Montandon , S. Meyer-Monard , A. Tichelli , T. Hardegger , U. Hess , M. Jotterand

2.58

Translocation t(6;16)in a Child with Acute Myeloid Leukaemia Confirmed by Spectral Karyotyping.

Oltová A., Kuglík P., Štěrba J., Sobotka J.

2.59

CGH ANALYSIS TO DETECT CHROMOSOMAL IMBALANCES IN TYPICAL B-CLL.

L. Ottaggio , A. Zunino , S. Zupo , M. Ferrarini , E. Rossi , M. Spriano , A. Abbondandolo , and S. Viaggi ,

2.60

Combined cytogenetic, interphase and multicolor fluorescence analysis reveals chromosome aberrations in almost all multiple myelomas

Dimitra Pantou, Helen Rizou, Haroula Tsarouha, Kostas Papanastasiou, Anastasia Pouli, Nikos Pandis, Marina Stamatellou, Georgia Bardi

2.61

The formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia

K. Paulsson , I. Panagopoulos , S. Knuutila , K. J. Jee , S. Garwicz T. Fioretos , F. Mitelman and B. Johansson .

2.62

G-band analysis, Spectral Karyotyping (SKY) and multiplex RT-PCR (mRT-PCR) in acute lymphatic leukaemia (ALL): does mRT-PCR add further diagnostic information?

Rikke Kølby Pedersen, Gitte B. Kerndrup, Niels Pallisgaard

2.63

High incidence of additional chromosomal changes in childhood acute lymphoblastic leukaemia with TEL/AML1 gene fusion

H. Pospíšilová , M. Jarošová , M. Holzerová , V. Mihál , B. Blažek , I.Lakomá , I. Prekopová , J. Hanzlíková , M. Divoká , Z. Pikalová and K. Indrák .

2.64

Deletion of 1p34-36 in three cases with myelodysplastic syndrome and characterisation by FISH

K.A. Rack , S. Vidrequin , J. Hamels , Y. Gillerot

2.65

Molecular heterogeneity of CML patients variant Philadelphia chromosome - survival implications

A Reid, B Huntly, C Grace, ARGreen and EPNacheva

2.66

A dicentric chromosome #18 and #21 masking trisomy 21 in Acute Myeloid Leukemia.

H. Rigana , R. La Starza , C. Sambani , K. Manola , A. Apostolidou , P. Matsouka and C. Mecucci .

2.67

Unexpected BCR-ABL fusion by FISH in acute lymphoblastic leukaemia

G. Reza Jalali, H.M. Robinson, M.Jabbar-Al-Obaidi, C.J.Harrison, M. Martineau

2.68

Additional cytogenetic events in pediatric acute lymphoblastic leukemia patients with t(12;21): deletion of the region 3' to the AML1 breakpoint (intron 2) and subsequent deletion of the normal TEL ALLELE

R. Rothman, L. Trakhtenbrot, B.Bielorai, H. Golan , G.Ishoev, M. Reichart, G. Rechavi, N. Amariglio and A.Toren

2.69

CYTOGENETIC AND FISH STUDY OF 84 PATIENTS WITH SPLENIC MARGINAL ZONE B-CELL LYMPHOMA

M. Salido, B. Espinet, L. Florensa, I. Granada, A. Domingo, M. Mollejo, JA. Martinez-Climent, JL. García, I. Benet, JM. Hernández, T. Vallespí, P. Martinez, MA. Piris, L. Zamora, E. Pérez-Vila, S Woessner, S Serrano, F. Solé.

2.70

The unbalanced t(1;9) in myeloproliferative disorders is a recurrent rearrangement involving the satellite II family of chromosome 1 and the satellite III of chromosome 9.

C. Sambani , R. La Starza , G. Voutsinas , H. Rigana , K. Manola , I. Wlodarska and C. Mecucci

2.71

PROGNOSTIC SIGNIFICANCE OF CHROMOSOMAL CHANGES IN BONE MARROW CELLS OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA

L. Sindelarova , K. Michalova , Z. Zemanova , J. Brezinova , S. Kurkova , J. Karban , A. Smolikova , J. Schwarz , E. Cmunt

2.72

t(11;20)(p15;q15) TRANSLOCATION IN DE-NOVO AML WITH NUP98-TOP1 GENE REARRANGEMENT AND EXPRESSION OF BOTH FUSION TRANSCRIPTS.

B. Sinigaglia, R. Maffei, P. Zucchini, M. Scaringi, P. Temperani.

2.73

Chromosomal origin of dmins, HSRs and amplicons, as determined by FISH.

A. Smith, L. St. Heaps, S. Diaz, L. Robson, P.Sharma.

2.74

Incidence of trisomy 8 and 9, deletion of D13S319 and D20S108 loci in non-treated polycytemia vera (PV) patients: an analysis of bone marrow cells using interphase fluorescence in situ hybridization

F. Solé , L. Zamora , B. Espinet , C. Besses , S. Woessner , S. Serrano , L Florensa .

2.75

CYTOGENTIC AND MOLECULAR ANALYSIS IN MYELOID LEUKEMIAS

Rashmi Talwar , Suraj Kumar AK , V P Choudhry , K.Kucheria

2.76

Translocations involving 6p22 in AML and their origins

J. Tchinda , S. Volpert , T. Neumann , Th. Buechner , W.E. Berdel , J. Horst

2.77

Three different types of MLL rearrangement involving chromosome 9 in childhood acute leukemia

A. Teigler-Schlegel , J. Bruch , S. Röttgers , U. Gamerdinger , S. Viehmann , M. Wilda , J .Harbott

2.78

Atypical BCR and ABL FISH patterns in chronic myeloid leukemia

K Tingström, B Hagström, F Jonsson, A Wahlin and I Golovleva

2.79

A new t(6;9)(p21;q34) in a patient with CML displays b3a2 bcr-abl sequence

B. Todorić-Živanović, D. Marisavljević, V. Čemerikić, K. Krtolica, Z. Magić, O. Marković

2.80

Clinical significance of the combined morphological, immunophenotypic and molecular cytogenetic analysis of hematological malignancies

L.Trakhtenbrot, R.Rothman, A. Toren, B. Bielorai, C. Kaplinsky, A. Shimoni, I. Hardan, M. Reichart, A. Nagler, F. Brok-Simoni, G. Rechavi and N. Amariglio

2.81

Comparative Genomic Hybridization Study of Multiple Myeloma

S. Volpert , J. Tchinda , M. Kropff , J. Kienast , W.E. Berdel , J. Horst

2.82

UTILIZATION OF FOUR MANTLE CELL LYMPHOMA CELL LINES: IN VITRO AND MURINE PRECLINICAL MODELS

M.E. Williams, D.G. Bebb, V.S. Lestou, C. Tucker, M. Chhanabhai, M. Bally, D. Horsman , D. Masin , M.J. Dyer and R. Klasa

2.83

Breakage-Fusion-Bridge cycles in adult acute lymphoblastic leukemia

A. Zagaria , L. Anelli , F. Albano , D. Pastore , V. Liso , M. Rocchi and G. Specchia ,

2.84

Trisomy 8 and additional iso(1q) in an ALL-L1 patient

A. Zamanı , C. Ucar , G. Durakbasi , R. Celik A. Acar